Comprehensive Biocatalysis Solutions
We offer a range of services to help you implement biocatalysis in your processes, from enzyme panel construction to reaction optimization.
Route Consultancy
We offer expert consultancy on biocatalytic retrosynthesis to help you identify where biocatalysis can have the greatest impact on your synthetic routes.
Our team of experienced scientists can analyze your synthetic routes or molecule to identify opportunities where biocatalytic steps can improve efficiency, sustainability, and cost-effectiveness. We provide tailored recommendations based on the latest developments in biocatalysis and our deep understanding of enzyme capabilities.
Route Analysis
Comprehensive evaluation of synthetic pathways
Strategic Recommendations
Expert advice on implementing biocatalytic steps
Enzyme Screening
Our high-throughput screening capabilities help you identify the best enzymes for your specific reactions.
With access to a whole host of analytical techniques, we can rapidly screen enzyme panels to find the most suitable candidates for your biocatalytic processes.
We have access to plate-readers, UPLC-DAD, UPLC-ELSD, LC-MS, GC-FID & GC-MS, amongst other equipment. Get in touch to discuss assays.
In addition, we have a close working relationship with Prozomix and can quickly screen their enzyme panels against your substrate.
We also offer bespoke enzyme panel development, with a range of bioinformatics techniques available to select enzymes for testing, from maximising diversity with a given sequence space, through to more targeted structure guided approaches.
High-Throughput Methods
Rapid evaluation and a range of analytical techniques
Bespoke panel development
Custom enzyme panels for your needs
Rapid Screening of Prozomix Panels
Ship your substrate to get it screened
Enzyme Engineering
We carefully select the best approach to improve enzyme activity, leveraging decades of enzyme engineering experience.
Our engineers use a comprehensive suite of approaches supported by computational methods to develop new biocatalysts with enhanced properties. We optimize enzymes for improved activity, selectivity, stability, and tolerance to process conditions, enabling more efficient and robust biocatalytic processes.
Rational Enzyme Design
Using molecular modeling and docking to carefully select and 'disyn' enzymes
Site Saturation Mutagenesis
Exploring sequence space to identify hotspots for further optimization
Directed Evolution
Combining site-specific and random mutagenesis to generate thousands of enzyme variants
High-Throughput Screening
Advanced analytics platform to rapidly evaluate enzyme performance
Reaction Optimization
We optimize reaction conditions to maximize yield, selectivity, and efficiency for your biocatalytic processes.
Our reaction optimization services help you develop robust and scalable biocatalytic processes. We systematically evaluate and optimize key parameters such as pH, temperature, substrate concentration, co-factor regeneration, and reaction media to maximize performance and ensure successful implementation at scale.
We employ iterative Design of Experiments (DoE) to explore multiple experimental factors simultaneously, allowing us to identify the optimal conditions for your specific reaction.
Furthermore we have access to an EasyMax 102 allowing us to generate data under relevant process conditions
Design of Experiments (DoE)
Systematic exploration of multi-factorial reaction conditions
Scale-up data
Reactions carried out using EasyMax 102 for data relevant to scale-up
Ready to Get Started?
Contact us to discuss how our services can help you implement biocatalysis in your processes.
Contact Us